Ramelteon Intermediate 1

Ramelteon Intermediate 1 - Names and Identifiers

Name	1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
Synonyms	8H-Indeno[5 RaMelteon I 7-tetrahydro- 4-b]furan-8-one Ramelteon Intermediate 1 1,2,6,7-tetrahydroindeno[5,4-b]furan-8-one 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one 1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one
CAS	196597-78-1
EINECS	1308068-626-2
InChI	InChI=1/C11H10O2/c12-9-3-1-7-2-4-10-8(11(7)9)5-6-13-10/h2,4H,1,3,5-6H2

Ramelteon Intermediate 1 - Physico-chemical Properties

Molecular Formula	C11H10O2
Molar Mass	174.2
Density	1.288±0.06 g/cm3(Predicted)
Melting Point	149-1510C
Boling Point	334.2±42.0 °C(Predicted)
Flash Point	165.595°C
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	White solid
Color	White to Off-White
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.624

Ramelteon Intermediate 1 - Risk and Safety

Hazard Class

IRRITANT

Ramelteon Intermediate 1 - Introduction

1,2, 6,7-tetrahydro-8h-indeno [5,4-b]furan-8-one, often abbreviated as DHCRF-8-one, is an oxygen-containing heterocyclic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
- DHCRF-8-ketone is a colorless crystal at room temperature and soluble in organic solvents such as chloroform, dimethylformamide and dichloromethane.
-It appears purple when dissolved in ethanol, with a characteristic purple absorption peak.
-Stable at room temperature and not easy to decompose.

Use:
- DHCRF-8-ketone has a wide range of applications in organic synthesis and can be used as an important intermediate to participate in a variety of organic synthesis reactions.
-It is often used to prepare indenofuran compounds with high chemical activity and biological activity.

Method:
- DHCRF-8-Ketones are prepared by a variety of methods, and one of the commonly used synthetic routes is through the oxidation of aldol.
-The detailed steps of the specific synthesis method include the reaction of the oxidizing reagent in the solution with aldol, and the synthesis is further purified by chemical treatment and product separation.

Safety Information:
-The toxicity and effects of DHCRF-8-ketone on humans have not been fully studied, so appropriate safety measures must be taken during operation.
-During operation, wear appropriate protective gloves and goggles to avoid contact with skin and eyes.
-When performing laboratory synthesis, reasonable process conditions and operating procedures should be followed to ensure the safety and controllability of the operation.
-When disposing of waste, it should be properly disposed of in accordance with local environmental regulations.

Last Update：2024-04-09 20:49:11